网站旧版  |  加入收藏
金沙贵宾会官方0029客服电话金沙贵宾会2999comQQ金沙贵宾会2999comQQ金沙贵宾会2999comQQ
金沙贵宾会官方0029微信服务号

产品目录

重组人线粒体凋亡诱导因子1(AIFM1)图片
产品货号:
JN0674
中文名称:
重组人线粒体凋亡诱导因子1(AIFM1)
英文名称:
Recombinant Human Apoptosis-Inducing Factor 1, Mitochondrial
产品规格:
10μg|50μg|500μg|1mg
发货周期:
1~3天
产品价格:
询价
本品由咱们的大肠杆菌表达系统制备而成,目的基因编码的Glu121-Asp613在N端含有His标签。

AIFM1质量控制:>95%(还原性SDS-PAGE)

AIFM1制剂:冻干品

AIFM1保存
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。

AIFM1复溶
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。

关于AIFM1
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e., caspase-independent fragmentation of chromosomal DNA. AIFM1 interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. It binds to DNA in a sequence-independent manner and plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells.
金沙贵宾会官方0029 |  关于咱们 |  联系咱们 |  在线咨询 |  网站地图
2013-2018 金沙贵宾会002999 京ICP备14007103号
XML 地图 | Sitemap 地图
Baidu
sogou